Fragrances and Flavours
A combined market value projected to be approx. $26bn by 2016
Early In vitro screening for genotoxicity
- Saves money and improves productivity
- Enables chemists to modify compounds to reduce genotoxicity without losing desirable properties
- Scalable for high throughput testing of large collections of compounds
- BlueScreen HC™ offers access to GADD45a up-regulation information
Further assays to understand the causes of positive results
- Follow up assays available
- Additional information to supplement early testing approach
Flavours and Taste Enhancers Testing
The global food ingredients market is worth in the order of €30Bn and covers all non-base foodstuffs. As well as the use of natural flavours there is an increasing use of designed flavours that are used to impart flavour or modify the levels of other components such as sugar and salt required to give acceptable taste.
New chemical entities that are Flavour Enhancers also need to be shown as safe and in this context need to be tested for their potential for generating genotoxic damage (genotoxicity).
Such testing becomes more expensive the later it occurs in the process of developing a new flavour candidate and so early detection of toxic liability is important.
Fragrance chemicals are found in a wide array of products from perfumes and cosmetics to consumer products such as washing detergents. The global market for fragrances is substantial $20B in 2012.
Estimation of genotoxicity hazard is conducted by RIFM/IFRA on behalf of the Fragrance industry and a palette of nearly 3,000 chemicals is available for fragrance creation by the member companies. In this way the safety of components in a fragrance mixture can be referenced whilst ensuring that the proprietary nature of the fragrance’ composition is preserved as a trade secret.
When to Screen
The earlier a compound is screened the greater the cost and time saving. The cost of rejecting a candidate based on genotox screening at the Lead Optimisation stage is more than 10x greater than if it had been rejected at the profiling stage. In addition, the opportunity to modify the compound, to make it safer, is correspondingly reduced.
Flavours Fragrance and Taste Enhancer (FFTE) sectors can now benefit from genotoxicity testing looking at the up-regulation of GADD45a gene due to the introduction of BlueScreen HC by Gentronix because it uses a luminescent reporter construct rather than a fluorescent GFP reporter. BlueScreen HC gives the same results as GreenScreen HC but has a wider scope of use that covers FFTE product development.