In Vitro Mammalian Cell Micronucleus Test (OECD 487)

gentronix_internal_headers_MNT cells


The Mammalian Micronucleus assay can be accessed through the Gentronix contract service:

Number of dose levels

A minimum of 10 doses will be tested to provide the cytotoxicity range required by the assay guidelines, and at least 3 – 6 dose levels will be analysed for micronuclei formation.

Number of replicates

Duplicate cultures will be tested.

Test compound requirement

Test substance requirements will be based on nature of the compound being tested, and the level of service required.

Turnaround time

For GLP studies, turnaround time from receipt of test article and characterisation/formulation information, to submission of the final report for sponsor approval is typically 8 – 12 weeks. For screening studies, initial results can be made available after 1-3 weeks, and final reporting after 3-6 weeks.

mnt turnaround times

An accelerated testing regime with reduced turnaround times, and other cell lines may also be available.  Please contact us to discuss your requirements.