Ames II and Ames MPF Test
SERVICE INFORMATION
Bacterial reverse mutation assays performed as fluctuation tests in a reduced liquid microplate format and exploiting a colorimetric read-out. Both Ames MPF and Ames II produce data with strong concordance to the classical Ames test, but require considerably lower test item amounts. This makes them ideally suited to high-throughput screening projects.
Advantages for Screening
Quick, cost effective, high quality results.
– Ames MPF:
• same strains as OECD 471
– Ames II:
• TA98 & TAmix covers G-C & A-T mutations
– Low compound requirement
– High-throughput capacity
| Ames MPF - Test strains | TA98, TA100, TA1535, TA1537 |
| Ames II – Test Strains | TA98, TAmix |
| Metabolic activation | Typically, induced rat liver S9, other sources available |
| Study Duration | < 3 Weeks |
| Endpoint | Mutagenicity |