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Gentronix Goes East

Posted on September 4, 2008 by Studio North

Innovative biotechnology company Gentronix (Manchester, UK) is pleased to annonounce a new agreement with LSG Corporation (Tokyo, Japan). The deal enables introduction of the GreenScreen® HC range of human cell-based genotoxicity assays access across Japan, allowing scientists to accelerate the pace of drug discovery and development. LSG has over 30 years’ experience providing researchers the tools and products required to solve even the toughest challenges within the life science arena. As a subsidiary of EPS Co., Ltd., one of the largest clinical research organisations (CROs) in Japan, LSG is the ideal partner to promote the benefits of GreenScreen assays in this…

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Gentronix use Abcellute Preserved Hepatocytes to Enhance in vitro Genotoxicity Testing

Posted on June 5, 2008 by Studio North

Safety assessment in drug discovery requires the in vitro genotoxicity assessment of metabolites. This is currently achieved by incubating compounds with liver extracts (‘S9’), because when genotoxicity tests were developed there was no reliable supply of fresh hepatocytes. Being able to use fresh hepatocytes for testing metabolites, instead of extracts with their limited metabolic activity, could be a major advance. This possibility has now moved a significant step closer. In the first stage of a major collaboration, Gentronix have successfully co-cultured their GreenScreen HC genotoxicity reporter cells with fresh hepatocytes preserved in Abcellute’s matrix in the presence of test material.…

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Manchester Scientists Highlighted for Contribution to UK Economy

Posted on June 2, 2008 by Studio North

Scientists and bioscience research groups from the University of Manchester and Manchester Metropolitan University have been highlighted for their contribution to the UK’s economic and social wellbeing. At a recent event at HM Treasury, “Bioscience: Biomillions”, run by the Biotechnology and Biological Sciences Research Council (BBSRC), Gentronix was among a wide range of research and innovation output from the two Manchester Universities highlighted for their economic and social impact. • Prof Sabine Flitsch, University of Manchester, is researching the relatively unexplored medical field of glycotherapeutics. She has developed a screening technology that can help understand the role of carbohydrate-protein interactions…

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Gentronix Launches New Genotoxic Metabolite Detection Assay

Posted on March 10, 2008 by Studio North

GreenScreen HC, the a human cell-based genotoxicity screening assay used in drug discovery programmes during lead compound optimisation and candidate selection, is now available with an S9 protocol to detect genotoxic metabolites. Potential pharmaceutical compounds which only present a genotoxicity hazard after metabolism, usually by the liver, are known as pro-genotoxins. The utility of GreenScreen HC has now been extended with a new protocol to detect pro-genotoxins as well as all common mechanistic classes of genotoxin including mutagens, clastogens, aneugens, and both topoisomerase and polymerase inhibitors. Link to published paper on the GreenScreen HC S9 assay.

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