Gentronix offfers a full GreenScreen HC contract testing service from its laboratory facilities in Manchester, UK. This provides an alternative route for the rapid and professional evaluation of a compound’s genotoxic liability without the need to install the in vitro assay in clients’ laboratories. The GreenScreen HC service routinely incorporates both testing in the absence and presence of metabolic activation using S9 fraction, the latter protocol employing flow cytometric cell scoring.
BlueScreen HC (+/- S9) is also available as a service and used principally for testing compounds with very high autofluorescence, or compounds supplied from the flavours, fragrence or taste enhancers industries.
Over 100 pharmaceutical and fine chemical companies in 16 countries have now used GreenScreen HC data as part of their genotoxicity profiling strategy.
Please contact Gentronix for further details of the GreenScreen HC & BlueScreen HC service and a quotation.
Testing with Gentronix has several advantages:
Low compound requirement
We request approximately 10 mg of pre-weighed material to be supplied per compound analysed. With pre-solubilisation in DMSO this allows testing up to typically 1 mg/ml unless limited by solubility or cytotoxicity and over 9 serial dilutions. Other samples formats are also acceptable.
Rapid turnaround
Gentronix aims to prepare, test and provide a full test report within 2 weeks of receipt of compounds and commencement of testing. Gentronix will also provide the complete set of data files, a detailed description of the protocol(s) followed and supporting documentation to assist with data interpretation.
Work with the experts in the assay
As the developers of the GreenScreen range of assays, Gentronix scientists will be able to provide expert advice on the testing protocols and data interpretation. Gentronix scientists also have wide experience in working with compounds with diverse physicochemical properties and can adapt protocols accordingly.
Test both with and without exogenous metabolic activation
Gentronix recommends that compounds are tested both with and without exogenous metabolic activation to give a complete picture of the compound’s genotoxic liability.
Scalable studies
Studies have previously been performed on as little as 1 to as many as over 1000 test compounds.
Click here to download a flyer with further information on the GreenScreen HC service offering
Please contact Gentronix for further details of the GreenScreen HC & BlueScreen HC service and a quotation.