The accuracy of GreenScreen HC reflects its unique combination of high sensitivity (ability to correctly identify genotoxins) and high specificity (ability to correctly identify non-genotoxins). Existing in vitro mammalian tests have low specificity, i.e. their false positive rate is high whilst bacterial tests suffer from poor sensitivity, i.e. their false negative rate is high.
Validation studies have shown that GreenScreen HC identifies all mechanistic classes of direct acting genotoxins including aneugens, topoisomerase inhibitors and DNA synthesis inhibitors. It can significantly reduce the number of ‘problem compounds’ in preclinical development, thus minimizing the need for expensive and time consuming mechanistic studies.